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KMID : 1059520110550050751
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Journal of the Korean Chemical Society
2011 Volume.55 No. 5 p.751 ~ p.755
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Resolution of Aryl α-Aminoalkyl Ketones on a Doubly Tethered Liquid Chromato graphic Chiral Stationary Phase Based on (+)-(18-Crown-6)-2,3,11,12- tetracarboxylic Acid
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Jin Kab-Bong
Kim Hee-Jin
Hyun Myung-Ho
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Abstract
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A doubly tethered chiral stationary phase (CSP) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied to the resolution of various aryl α-aminoalkyl ketones with the use of 80% ethanol in water containing 10 mM sulfuric acid as a mobile phase. The chiral resolution was quite successful, the separation factors (α) and the resolutions (RS) being in the range of 1.39-2.05 and 3.18-5.22, respectively. The separation factors (α) on the doubly tethered CSP were slightly worse than those on the corresponding singly tethered CSP. However, the resolutions (RS) on the doubly tethered CSP were generally greater than those on the corresponding singly tethered CSP. The chromatographic behaviors for the resolution of aryl α-aminoalkyl ketones on the doubly tethered CSP were demonstrated to be dependent on the type and the content of the organic and acidic modifiers in aqueous mobile phase and the column temperature.
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KEYWORD
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Aryl α-aminoalkyl ketone, Chiral stationary phase, (+)-(18-Crown-6)-2, 3, 11, 12-tetracarboxylic acid, Liquid chromatography, Resolution
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